Low Libido: Biomarker Factors Worth Looking At

Low libido is common and often has more than one cause. Hormones are one piece. Stress, sleep, relationship dynamics, medication side effects and mental health are all major contributors. Biomarker testing can highlight underlying factors that may contribute to how you feel. It is not a diagnostic tool. The information below is educational and does not replace personalised medical advice.

Hormonal biomarkers worth checking

Testosterone (men): Total and free testosterone, alongside SHBG, give the fullest picture. Levels naturally decline with age but very low readings may warrant clinical discussion.

Oestradiol and progesterone (women): Particularly relevant in perimenopause and menopause. Cycle day matters for premenopausal women.

Prolactin: Raised levels can suppress libido in both sexes.

Thyroid markers: Underactive thyroid can lower libido.

SHBG: Binds sex hormones. High SHBG reduces free, active hormone available.

Non-hormonal factors that matter just as much

Sleep deprivation, chronic stress, antidepressants (particularly SSRIs), alcohol, relationship issues, body image concerns and mental health all affect libido. None of these show on a blood test.

Consider these alongside any results.

When low libido needs clinical input

Sudden loss of libido, alongside erectile dysfunction or other significant changes, or libido changes accompanied by depression or relationship distress all benefit from a clinician's assessment.

Chxhealth panels that cover these markers

The panels below cover the biomarkers discussed above. Each comes with a plain English PDF report, lab analysis by Randox (UKAS, ISO 15189), and the phlebotomy fee included in the price.

Related biomarker guides

Read more about the markers discussed in this guide:

• Testosterone
• Oestradiol
• SHBG
• Prolactin
• TSH

FAQs

Can a blood test fix low libido?

It can identify hormonal contributors that may be addressable. It cannot address relational, psychological or lifestyle factors.

When is the best time of day to test testosterone?

Morning, between 7am and 10am, when testosterone is naturally highest.

Does low libido always mean low testosterone?

No. Many men with low libido have normal testosterone. The reverse is also true.

Can SSRIs cause low libido?

Yes, sexual side effects are a recognised effect of many antidepressants. Discuss with your prescribing clinician if this is a concern.

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About this guide. These tests provide biomarker data only. They do not diagnose any condition. Always discuss your results with a qualified clinician before making decisions about your health, medication or lifestyle. Educational content for general awareness. Chxhealth provides biomarker and genetic data. We do not diagnose, treat or prescribe. For medical advice about your health or results, please speak to a qualified clinician.